I didn't know where to put the question, I was hoping someone knows the utility/app, perhaps a macro that can help to rotate part of the screen.
Primarily I was looking in the Zoom option in Accessibility settings:
Zoom Style: Picture-in-picture
Now the only setting I am missing is if I could change the orientation of the preview Picture-in-picture. It is unfortunate that Illustrator doesn't support 'Rotate Artboard' function (Like Photoshop do) hence the question.