Which shortcuts? This sysdiagnose is a low level feature, it is not meant to ever be invoked except in weird debugging situations. Unfortunately the concept of a Hyper key made this a poor choice of keystroke, but it is understandable in the absence of the Hyper key to make it as complex as possible.
There are a few other hard-wired shortcuts, like Command-Tab (which Keyboard Maestro goes way out of its way to work around). But I don't see any that can't be changed in Mojave that used to be changeable…?