How to manage keyboard shortcut / combination issues on the border or keyboard maestro and karabiner elements

Have you tried just setting your hotkeys as you wish? For me, it is enough to set a macro hotkey to Option-2. That then invokes the macro when run. Disabling the macro (or putting it in a group that excludes a writing app should I want to use the native key combo) still allows me to get ™ should that ever be needed.

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