Profiles Not Switching For Applications

I had a mini and now added a 15 button
(and upgraded the software to 4.5.1)

Now the profiles set up to be application-specific are not switching
It just always stays with the default

What do I need to nudge to make it work again?

I tried unplugging the 15, but the mini no longer switches when using alone.
Stopped and started Stream deck - still not working

Never mind
Looks like it does not switch while the editor is open
New user error