I use patterns of hot keys for different tasks. So, in my case ⌃⌥⌘ and a single letter is when I want to "go" somewhere like to a website or to a folder. So, ⌃⌥⌘G for Google or a folder beginning with the letter G.
I use ⌃ and a letter when I want to open an App. So ⌃P for Photoshop and Pages and Photos. And ⌃C for Calendar and Contacts and Chrome.
But for shortcuts inside individual Apps I use specific shortcut keys and palettes. Here is my Palette for Photoshop for example. (This is a regular Group Palette not a Conflict Palette).
You'll notice that the above Palette lists the shortcut key. So, this in itself makes if easy to learn the keys for things I do a lot (which was your original question that started this thread).
Everyone will work out their own system - there is no "right" way to do this stuff - which is one of the many things that makes Keyboard Maestro so powerful.
But it's great to get insights into the ways you are all doing this.
I know you are asking @JMichaelTX but allow me to butt in. I do all my text expansions on Keyboard Maestro. I dropped Text Expander in fact. I am told, Peter Lewis himself says not to load up to much on expansions: it takes up a lot of file space or something I don't remember. However for the number I have it works fine.
@tudor_eynon: thanks for butting in. The question was directed @JMichaelTX because he wrote such an expansive reply, but that does not mean someone else is not allowed to answer. At the end of the day what counts is to get an answer, which you provided perfectly
I am using Espanso myself, a very light-weight text expander which apparently is quite powerful. I say apparently because I use it for only very simple expansions.