It might indicate an imperfect approach if one cannot recall most hotkeys ("muscle memory"), but not when setting up hotkeys (planning). As I have mentioned in previous discussions on the forum, I keep a list of all hotkeys which I update as I either define or become aware of a "new" hotkey (latest version: a Numbers spreadsheet with two columns). Yes it's a geeky administration task, but it pays off for me.
Absolutely. This is why I bang on about (and bang on) programmable keyboards every once in a while here (example). I am mentioning the subject again because @SirCharles seeks "more logical/comfortable placement". These are matters that can be put fully under a user's control, with the right hardware.
A powerful gateway dr*g. 