Yep, especially now that it's been turned into an app that's been posted on many very popular Mac sites, I expect this most-useful modification will stop working with the next macOS update. 
-rob.
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Broke OCR macros for me. Not sure if this is a common issue.
Assuming you are using English and Keyboard Maestro 11.x, try using the Apple Text Recognition instead of the Tesseract version. It seems (at least for my initial testing) that the Tesseract code aborts with a memory corruption frequently on Sequoia. Whether that it a bug in Tesseract or Sequoia I don't know. Either way, I'm not sure I'll be able to fix it.
I just saw these posts about Sequoia not allowing applications to have "global hotkeys where Option or Shift+Option are the only modifiers"
https://shottr.cc/kb/sequoia
https://developer.apple.com/forums//thread/763878?src=push&answerId=804374022#804374022
I don't have any problems using Option or Shift-Option hotkeys in Keyboard Maestro in Sequoia so far, though. But I thought I'd bring it to everyone's attention.
That only applies to sandboxed apps that want to let the user assign hot keys. Keyboard Maestro is not sandboxed.
-rob.
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