I’m finding that KM is incompatible with much of other software on my Mac. Adobe CC updater for example will not work as expected unless I quite the KM Engine. Many other app will not become active unless I quit the Engine.
I have no other reports of this and no idea why the Adobe updater would have any issues with Keyboard Maestro Engine. I’m sure if there was widespread issues with this I would long ago have heard of it since large numbers of people use Keyboard Maestro and Adobe CC, so something else is going on on your Mac.