What's that? Do you mean the native Stream Deck plugin for Keyboard Maestro?
Here's a great post by @cdthomer that should help explain the differences between KM Link and the native plugin.
It would be helpful if you posted screenshots of your macro and SD configuration. Hard to know what's wrong without that kind of info.
If everything appears to be in order, it's worth making sure that the macro in question is placed in a macro group that is available at the time you're trying to trigger it. If the macro group is set to be available in specific apps and one of those apps isn't front-most at the time you try to trigger the macro, it won't run. You may already be aware of this, but it does catch some people out.