Triggering a macro in a minimized window

I usually I call my clients while I am reviewing their charts. I have a macro that would call the client's phone number using Google Voice. The question is while I am studying the chart, is it possible to trigger a macro when the application which in this case is the browser is minimized? Or there is no other option but to maximize the Chrome application to be able to use the macro? In other words, is there a way to trigger a macro for an application window that is minimized?

It depends what the macro is doing and how. Can you give a bit of detail and, ideally, post the macro itself?