@peternlewis, I found this solution RIGHT after I posted, sorry. This will work well for part 1 of my Chrome Tabs question! How to use Chrome URL as a macro trigger?
I'm still curious what the best way to exclude all the other sites that I do not want the site-specific commands to run on.
Also, Do I have to create a second macro for each key that I want, for instance, two key taps, to trigger another key combination? I'm trying to figure out the best way to streamline this without creating 24 to 48 macros per site/application. Thanks again.