I have a couple of apps that are memory and CPU intensive. When I use them, I only use them and want to shut down as many other apps as possible. I'd like to be able to turn off the Little Snitch network filter when I run the macro to shut down apps and then to turn it on again when I run the macro to enable all the apps I turned off before.
Just as well to ignore it… Little Snitch's developer is adamantly opposed to any sort of automation, believing that allowing any way to automate the application is a potential security hole that would allow a malicious app to deactivate it.
There used to be a way to turn off the Network Filter using Keyboard Maestro and scripting an interaction with the preferences window, but not long after I wrote about how to do it, the developer changed the window in a way that makes it basically impossible now.
It makes sense to disallow automation, but a better way would be to require a password to change the preferences. Then you could still have automation, you just need to have the password.