Unfortunately, no. There is currently no easy way to do that.
By default, Keyboard Maestro basis application selection on the path, so as long as the path of the application does not change, then you should have no issue. But if the path is something like “/Applications/Adobe App 2019.app” and it changes each time, then that will be considered a different app (so that you can, for example, have both applications installed with different macros). If the application cannot be fond at that path, Keyboard Maestro will look for the application based on the Bundle ID.
With Keyboard Maestro 9, when selecting an application, you can also select to base the application only on the path, or only on the Bundle ID. If you did the latter, and the path changed, then Keyboard Maestro should not be affected and just use the new path. But if you have both, then confusion may ensue.