XK-24 Keyboard Mapping: Chrome tabs and Modifier Keys

Can you give us some detailed examples of what you are trying to do?
It is hard for me to concepulize the need for 24-48 unique macros/workflows for every web site.
Perhaps take two web sites and show us the details of how they are different.

Since I don't understand your basic need, I'm probably shooting in the dark here, but my approach generally would be:

  1. Trigger a macro on Focused Window Title Changes trigger
  2. Get the URL, Domain, or whatever key identifying info you need to ID the site
  3. Setup a Switch or Case action based on that ID
  4. Then in each Case (for a specific site), set whatever data you need to, including enabling/disabling other macros, showing a specific palette, etc.

I'll stop here until I know more about your use case.

Please read:
Tip: How Do I Get The Best Answer in the Shortest Time?